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Scientific Publications


Breast Fibroadenoma

R. Kovatcheva, K. Zaletel, J. Vlahov, J. StoinovLong-term efficacy of ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma; Journal of Therapeutic Ultrasound; 2017

MC. Peek, M. Ahmed, J. Scudder, R. Baker, SE. Pinder, M. Douek; High intensity focused ultrasound in the treatment of breast fibroadenomata: results of the HIFU-F trial; Int J Hyperthermia; 2016

M. Hahn, B. Böer, M. Marx, E. Oberlechner, R. Fugunt, I. Gruber, G. Helms, C. Röhm, S. Brucker; Thermosurgical Ablation of Breast Fibroadenoma First experiences with a HIFU system; Senologie, 2016

R. Kovatcheva, J.-N. Guglielmina, M. Abehsera, L. Boulanger, N. Laurent, E. PonceletUltrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma—a multicenter experience; Journal of Therapeutic Ultrasound (2015) 3:1

B. Cavallo Marincola, F. Pediconi, M. Anzidei, E. Miglio, L. Di Mare, M. Telesca, M. Mancini, G. D’Amati, M. Monti, C. Catalano, A. NapoliHigh-intensity focused ultrasound in breast pathology: non-invasive treatment of benign and malignant lesions; Expert Rev. Med. Devices Early online, 1–9, 2014



Y. Korkusuz, D. Gröner, N. Raczynski, O. Relin, Y. Kingeter, F. Grünwald, C. Happel; Thermal ablation of thyroid nodules: are radiofrequency ablation, microwave ablation and high intensity focused ultrasound equally safe and effective methods?; Eur Radiol; 2017

M. Sennert, C. Happel, Y. Korkusuz, F. Grünwald, B. Polenz, D. Gröner; Further Investigation on High Intensity Focused Ultrasound (HIFU) Treatment for Thyroid Nodules: Effectiveness Related to Baseline Volumes; Acad Radiol; 2017

B. Lang, Y. Woo, C. Wong; K. Chiu; Single-Session High-Intensity Focused Ultrasound Treatment for Persistent or Relapsed Graves Disease: Preliminary Experience in a Prospective Study. Radiology. 2017 Jul 20:162776

B. Lang, Y. Woo, C. Wong; High-Intensity Focused Ultrasound for Treatment of Symptomatic Benign Thyroid Nodules; Radiology; 2017

B. Lang, C. Wong, E. MaSingle-session high intensity focussed ablation (HIFU) versus open cervical hemithyroidectomy for benign thyroid nodule: analysis on early efficacy, safety and voice quality; International Journal of Hyperthermia; 2017

B. Lang, Y. Woo, K. Chiu; High-intensity focused ablation (HIFU) of single benign thyroid nodule rarely alters underlying thyroid function; International Journal of Hyperthermia; 2017

B. Lang, Y. Woo, K. Chiu; Single-session High Intensity Focused Ultrasound (HIFU) Treatment in Large-sized Benign Thyroid Nodules; Thyroid, March 2017

RD. Kovatcheva, K. ZaletelHigh-intensity focused ultrasound for thyroid nodule ablation: the evidence to date; Reports in Medical Imaging. 2017:10 9–16

RD. Kovatcheva, JD. Vlahov, JI. Stoinov, K. Zaletel; Benign Solid Thyroid Nodules: US-guided High-Intensity Focused Ultrasound Ablation—Initial Clinical Outcomes; Radiology. 2015 Aug;276(2):597-605

H. Korkusuz, N. Fehre, M. Sennert, C. Happel, F. Grünwald; Localized thyroid tissue ablation by high intensity focused ultrasound: Volume reduction, effects on thyroid function and immune responseRofo. (2015) Nov;187(11):1011-1015.

H. Korkusuz, N. Fehre, M. Sennert, C.Happel, F. GrünwaldVolume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU); Journal of Therapeutic Ultrasound (2015) 3:4

H. Korkusuz, N. Fehre, M. Sennert, C. Happel, F. Grünwald; Early assessment of high-intensity focused ultrasound treatment of benign thyroid nodules by scintigraphic means; Journal of Therapeutic Ultrasound 2014, 2:18, 2014

H. Korkusuz, M. Sennert, N. Fehre, C. Happel, F. GrünwaldLocal thyroid tissue ablation by high-intensity focused ultrasound: Effects on thyroid function and first human feasibility study with hot and cold thyroid nodules; International Journal of Hyperthermia, Early Online: 1–6, 2014

Esnault O, Franc B, Ménégaux F, A. Rouxel, De Kerviler E, Bourrier P, Lacoste F, Chapelon J.Y, Leenhardt L High-Intensity Focused Ultrasound Ablation of Thyroid Nodules: First Humean Feasibility Study; Thyroid, Volume 21, Number 9, 2011

O. Esnault, A. Rouxel, E. Le Nestour, G. Gheron, L. Leenhardt Minimally Invasive Ablation of a Toxic Thyroid Nodule by High-Intensity Focused Ultrasound; AJNR Am J Neuroradiol (2010)

Esnault O, Franc B, Chapelon JY Localized ablation of thyroid tissue by High-Intensity Focused Ultrasound (HIFU): Improvement of noninvasive tissue necrosis methods; Thyroid, October 2009, 19(10): 1085-1091

Esnault O, Franc B, Leenhardt L, Rouxel A, Ménégaux F, Lacoste F ; High-Intensity Focused Ultrasound (Hifu) Treatment For Thyroid Nodules: Experimental And First Clinical Studies ;proceedings ISTU 2006

Esnault 0, Franc B, Chapelon JY, Lacoste F ; Localized Ablation of Thyroid Tissue by High-Intensity Focused Ultrasound: an Alternative to Surgery?; proceedings ISTU 2005

Esnault O., Franc B., Monteil J.-P., Chapelon J.-Y ; High-Intensity Focused Ultrasound for Localized Thyroid Tissue Ablation: Preliminary Experimental Animal Study; Thyroid, Volume 14, Number 12, 2004

Roussanka D. Kovatcheva; Jordan D. Vlahov; Julian I. Stoinov; Georgi G. Kirilov; Stephan G. Krivoshiev; Francoise Arnaud ; Catherine Ortuno; Tilman B. Drueke; High-intensity focussed ultrasound (HIFU) treatment in uraemic secondary hyperparathyroidism; Nephrology Dialysis Transplantation 2011; doi: 10.1093/ndt/gfr590.

Kovatcheva RD, Vlahov JD, Shinkov AD, Borissova AM, Hwang JH, Arnaud F, Hegedüs L. ; High-intensity focused ultrasound to treat primary hyperparathyroidism: a feasibility study in four patients;AJR Am J Roentgenol. 2010 Oct;195(4):830-5

R. Kovatcheva, J Vlahov, AM Borissova, S Zaharieva, JH Hwang ; High Intensity Focused Ultrasound: A Novel Non-Invasive Treatment for Hyperparathyroidism; présenté au congrès de l’American Society of Nephrology, San Diego, Octobre 2009

R Kovatcheva, F Arnaud, F Lacoste ; Contrast Agent Ultrasonography Before and After HIFU Treatment of Parathyroid Glands; présenté au 9th International Symposium on Therapeutic Ultrasound, Aix en Provence, Septembre 2009


Echopulse® is a medical device designed and marketed by Theraclion for use by health professionals in treating patients with breast fibroadenomas and benign thyroid nodules. It is a regulated health product and, in accordance with the above Act, it bears the CE marking. Consult your health professional before any procedure.

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